Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair
Joint Authors
Leite Rodrigues de Oliveira, Alexandre
Perussi Biscola, Natalia
Politti Cartarozzi, Luciana
Ferreira Junior, Rui Seabra
Barraviera, B.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-29
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Brachial plexus lesion results in loss of motor and sensory function, being more harmful in the neonate.
Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant.
Thus, P2 neonatal Lewis rats were divided into three groups: AX: sciatic nerve axotomy (SNA) without treatment; AX+FS: SNA followed by end-to-end coaptation with fibrin sealant derived from snake venom; AX+CFS: SNA followed by end-to-end coaptation with commercial fibrin sealant.
Results were analyzed 4, 8, and 12 weeks after lesion.
Astrogliosis, microglial reaction, and synapse preservation were evaluated by immunohistochemistry.
Neuronal survival, axonal regeneration, and ultrastructural changes at ventral spinal cord were also investigated.
Sensory-motor recovery was behaviorally studied.
Coaptation preserved synaptic covering on lesioned motoneurons and led to neuronal survival.
Reactive gliosis and microglial reaction decreased in the same groups (AX+FS, AX+CFS) at 4 weeks.
Regarding axonal regeneration, coaptation allowed recovery of greater number of myelinated fibers, with improved morphometric parameters.
Preservation of inhibitory synaptic terminals was accompanied by significant improvement in the motor as well as in the nociceptive recovery.
Overall, the present data suggest that acute repair of neonatal peripheral nerves with fibrin sealant results in neuroprotection and regeneration of motor and sensory axons.
American Psychological Association (APA)
Perussi Biscola, Natalia& Politti Cartarozzi, Luciana& Ferreira Junior, Rui Seabra& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. 2016. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113371
Modern Language Association (MLA)
Perussi Biscola, Natalia…[et al.]. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1113371
American Medical Association (AMA)
Perussi Biscola, Natalia& Politti Cartarozzi, Luciana& Ferreira Junior, Rui Seabra& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113371
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113371