Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair

Joint Authors

Leite Rodrigues de Oliveira, Alexandre
Perussi Biscola, Natalia
Politti Cartarozzi, Luciana
Ferreira Junior, Rui Seabra
Barraviera, B.

Source

Neural Plasticity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-06-29

Country of Publication

Egypt

No. of Pages

19

Main Subjects

Biology
Medicine

Abstract EN

Brachial plexus lesion results in loss of motor and sensory function, being more harmful in the neonate.

Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant.

Thus, P2 neonatal Lewis rats were divided into three groups: AX: sciatic nerve axotomy (SNA) without treatment; AX+FS: SNA followed by end-to-end coaptation with fibrin sealant derived from snake venom; AX+CFS: SNA followed by end-to-end coaptation with commercial fibrin sealant.

Results were analyzed 4, 8, and 12 weeks after lesion.

Astrogliosis, microglial reaction, and synapse preservation were evaluated by immunohistochemistry.

Neuronal survival, axonal regeneration, and ultrastructural changes at ventral spinal cord were also investigated.

Sensory-motor recovery was behaviorally studied.

Coaptation preserved synaptic covering on lesioned motoneurons and led to neuronal survival.

Reactive gliosis and microglial reaction decreased in the same groups (AX+FS, AX+CFS) at 4 weeks.

Regarding axonal regeneration, coaptation allowed recovery of greater number of myelinated fibers, with improved morphometric parameters.

Preservation of inhibitory synaptic terminals was accompanied by significant improvement in the motor as well as in the nociceptive recovery.

Overall, the present data suggest that acute repair of neonatal peripheral nerves with fibrin sealant results in neuroprotection and regeneration of motor and sensory axons.

American Psychological Association (APA)

Perussi Biscola, Natalia& Politti Cartarozzi, Luciana& Ferreira Junior, Rui Seabra& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. 2016. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113371

Modern Language Association (MLA)

Perussi Biscola, Natalia…[et al.]. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1113371

American Medical Association (AMA)

Perussi Biscola, Natalia& Politti Cartarozzi, Luciana& Ferreira Junior, Rui Seabra& Barraviera, B.& Leite Rodrigues de Oliveira, Alexandre. Long-Standing Motor and Sensory Recovery following Acute Fibrin Sealant Based Neonatal Sciatic Nerve Repair. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113371

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1113371