Synaptic WntGSK3β Signaling Hub in Autism
Joint Authors
Caracci, Mario O.
Ávila, Miguel E.
De Ferrari, Giancarlo V.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hundreds of genes have been associated with autism spectrum disorders (ASDs) and the interaction of weak and de novo variants derive from distinct autistic phenotypes thus making up the “spectrum.” The convergence of these variants in networks of genes associated with synaptic function warrants the study of cell signaling pathways involved in the regulation of the synapse.
The Wnt/β-catenin signaling pathway plays a central role in the development and regulation of the central nervous system and several genes belonging to the cascade have been genetically associated with ASDs.
In the present paper, we review basic information regarding the role of Wnt/β-catenin signaling in excitatory/inhibitory balance (E/I balance) through the regulation of pre- and postsynaptic compartments.
Furthermore, we integrate information supporting the role of the glycogen synthase kinase 3β (GSK3β) in the onset/development of ASDs through direct modulation of Wnt/β-catenin signaling.
Finally, given GSK3β activity as key modulator of synaptic plasticity, we explore the potential of this kinase as a therapeutic target for ASD.
American Psychological Association (APA)
Caracci, Mario O.& Ávila, Miguel E.& De Ferrari, Giancarlo V.. 2016. Synaptic WntGSK3β Signaling Hub in Autism. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113387
Modern Language Association (MLA)
Caracci, Mario O.…[et al.]. Synaptic WntGSK3β Signaling Hub in Autism. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113387
American Medical Association (AMA)
Caracci, Mario O.& Ávila, Miguel E.& De Ferrari, Giancarlo V.. Synaptic WntGSK3β Signaling Hub in Autism. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113387