Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in Uninjured and Injured Spinal Cord

Joint Authors

Garraway, Sandra M.
Huie, J. Russell

Source

Neural Plasticity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-09-19

Country of Publication

Egypt

No. of Pages

19

Main Subjects

Biology
Medicine

Abstract EN

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of signaling molecules.

Since its discovery over three decades ago, BDNF has been identified as an important regulator of neuronal development, synaptic transmission, and cellular and synaptic plasticity and has been shown to function in the formation and maintenance of certain forms of memory.

Neural plasticity that underlies learning and memory in the hippocampus shares distinct characteristics with spinal cord nociceptive plasticity.

Research examining the role BDNF plays in spinal nociception and pain overwhelmingly suggests that BDNF promotes pronociceptive effects.

BDNF induces synaptic facilitation and engages central sensitization-like mechanisms.

Also, peripheral injury-induced neuropathic pain is often accompanied with increased spinal expression of BDNF.

Research has extended to examine how spinal cord injury (SCI) influences BDNF plasticity and the effects BDNF has on sensory and motor functions after SCI.

Functional recovery and adaptive plasticity after SCI are typically associated with upregulation of BDNF.

Although neuropathic pain is a common consequence of SCI, the relation between BDNF and pain after SCI remains elusive.

This article reviews recent literature and discusses the diverse actions of BDNF.

We also highlight similarities and differences in BDNF-induced nociceptive plasticity in naïve and SCI conditions.

American Psychological Association (APA)

Garraway, Sandra M.& Huie, J. Russell. 2016. Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in Uninjured and Injured Spinal Cord. Neural Plasticity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113423

Modern Language Association (MLA)

Garraway, Sandra M.& Huie, J. Russell. Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in Uninjured and Injured Spinal Cord. Neural Plasticity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1113423

American Medical Association (AMA)

Garraway, Sandra M.& Huie, J. Russell. Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in Uninjured and Injured Spinal Cord. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1113423

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1113423