“Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes
Joint Authors
Olivieri, Fabiola
Ceriello, Antonio
Prattichizzo, Francesco
De Nigris, Valeria
La Sala, Lucia
Procopio, Antonio Domenico
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aging is a complex phenomenon driven by a variety of molecular alterations.
A relevant feature of aging is chronic low-grade inflammation, termed “inflammaging.” In type 2 diabetes mellitus (T2DM), many elements of aging appear earlier or are overrepresented, including consistent inflammaging.
T2DM patients have an increased death rate, associated with an incremented inflammatory score.
The source of this inflammation is debated.
Recently, the senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammaging in both aging and T2DM.
Different pathogenic mechanisms linked to T2DM progression and complications development have been linked to senescence and SASP, that is, oxidative stress and endoplasmic reticulum (ER) stress.
Here we review the latest data connecting oxidative and ER stress with the SASP in the context of aging and T2DM, with emphasis on endothelial cells (ECs) and endothelial dysfunction.
Moreover, since current medical practice is insufficient to completely suppress the increased death rate of diabetic patients, we propose a SASP-centered view of T2DM as a futuristic therapeutic option, possibly opening new prospects by moving the attention from one-organ studies of diabetes complications to a wider targeting of the aging process.
American Psychological Association (APA)
Prattichizzo, Francesco& De Nigris, Valeria& La Sala, Lucia& Procopio, Antonio Domenico& Olivieri, Fabiola& Ceriello, Antonio. 2016. “Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113650
Modern Language Association (MLA)
Prattichizzo, Francesco…[et al.]. “Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113650
American Medical Association (AMA)
Prattichizzo, Francesco& De Nigris, Valeria& La Sala, Lucia& Procopio, Antonio Domenico& Olivieri, Fabiola& Ceriello, Antonio. “Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113650
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113650