Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a neurodegenerative disorder involving the loss of neurons in the brain which leads to progressive memory loss and behavioral changes.
To date, there are only limited medications for AD and no known cure.
Nitric oxide (NO) has long been considered part of the neurotoxic insult caused by neuroinflammation in the Alzheimer’s brain.
However, focusing on early developments, prior to the appearance of cognitive symptoms, is changing that perception.
This has highlighted a compensatory, neuroprotective role for NO that protects synapses by increasing neuronal excitability.
A potential mechanism for augmentation of excitability by NO is via modulation of voltage-gated potassium channel activity (Kv7 and Kv2).
Identification of the ionic mechanisms and signaling pathways that mediate this protection is an important next step for the field.
Harnessing the protective role of NO and related signaling pathways could provide a therapeutic avenue that prevents synapse loss early in disease.
American Psychological Association (APA)
Balez, Rachelle& Ooi, Lezanne. 2015. Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113853
Modern Language Association (MLA)
Balez, Rachelle& Ooi, Lezanne. Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113853
American Medical Association (AMA)
Balez, Rachelle& Ooi, Lezanne. Getting to NO Alzheimer’s Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric Oxide. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113853