Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Metabolic syndrome has been linked to an increased risk of chronic kidney disease.
The underlying pathogenesis of metabolic disease-related renal injury remains obscure.
Accumulating evidence has shown that NADPH oxidase is a major source of intrarenal oxidative stress and is upregulated by metabolic factors leading to overproduction of ROS in podocytes, endothelial cells, and mesangial cells in glomeruli, which is closely associated with the initiation and progression of glomerular diseases.
This review focuses on the role of NADPH oxidase-induced oxidative stress in the pathogenesis of metabolic disease-related renal injury.
Understanding of the mechanism may help find potential therapeutic strategies.
American Psychological Association (APA)
Wan, Cheng& Su, Hua& Zhang, Chun. 2016. Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114242
Modern Language Association (MLA)
Wan, Cheng…[et al.]. Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114242
American Medical Association (AMA)
Wan, Cheng& Su, Hua& Zhang, Chun. Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An Update. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114242