Blood Levels of OxidantAntioxidant Parameters in Rats Infected with Toxoplasma gondii
Joint Authors
Bahrami, Somayeh
Shahriari, Ali
Tavalla, Mehdi
Azadmanesh, Somayeh
Hamidinejat, Hossein
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Toxoplasmosis is a common parasitic infection in the world.
Since increased free radicals and oxidative stress are reported in many parasitic diseases the purpose of the present study was to evaluate the oxidative stress in acute and chronic toxoplasmosis.
RH strains of Toxoplasma tachyzoites were used in the present study.
Twenty-five female rats were infected with the parasite while 25 other rats were as the control group that received normal saline.
Zero-, 5-, 7-, 10-, and 45-day postinfection (DPI) blood samples were taken.
Some parameters related to oxidant and antioxidants such as antioxidant enzymes, malondialdehyde, and total antioxidant capacity were measured.
On day 7 after infection, GPX activity and GSH level were significantly increased and in the mentioned day the amount of total antioxidant capacity was significantly reduced.
In other cases, there were no significant differences between the groups in different days.
Overall, based on the results it seems that, on day 7 after infection, in infected rats responses to oxidative stress were triggered and led to decrease of total antioxidant capacity.
Furthermore, glutathione was increased to cope with stress.
It seems that probably antioxidant defense system entered the infection to the chronic phase and changed the parasites stage.
American Psychological Association (APA)
Bahrami, Somayeh& Shahriari, Ali& Tavalla, Mehdi& Azadmanesh, Somayeh& Hamidinejat, Hossein. 2016. Blood Levels of OxidantAntioxidant Parameters in Rats Infected with Toxoplasma gondii. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114283
Modern Language Association (MLA)
Bahrami, Somayeh…[et al.]. Blood Levels of OxidantAntioxidant Parameters in Rats Infected with Toxoplasma gondii. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114283
American Medical Association (AMA)
Bahrami, Somayeh& Shahriari, Ali& Tavalla, Mehdi& Azadmanesh, Somayeh& Hamidinejat, Hossein. Blood Levels of OxidantAntioxidant Parameters in Rats Infected with Toxoplasma gondii. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114283