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Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure
Joint Authors
Cadoná, Francine C.
Scola, Gustavo
Duong, Angela
Machado, Alencar Kolinski
Andreazza, Ana Cristina
da Silva, Tatiane Morgana
Boligon, Aline Augusti
do Nascimento, Vanusa
Ribeiro, Euler Esteves
da Cruz, Ivana Beatrice Mânica
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Neuropsychiatric diseases, such as bipolar disorder (BD) and schizophrenia (SCZ), have a very complex pathophysiology.
Several current studies describe an association between psychiatric illness and mitochondrial dysfunction and consequent cellular modifications, including lipid, protein, and DNA damage, caused by cellular oxidative stress.
Euterpe oleracea (açaí) is a powerful antioxidant fruit.
Açaí is an Amazonian palm fruit primarily found in the lowlands of the Amazonian rainforest, particularly in the floodplains of the Amazon River.
Given this proposed association, this study analyzed the potential in vitro neuropharmacological effect of Euterpe oleracea (açaí) extract in the modulation of mitochondrial function and oxidative metabolism.
SH-SY5Y cells were treated with rotenone to induce mitochondrial complex I dysfunction and before and after we exposed the cells to açaí extract at 5 μg/mL.
Treated and untreated cells were then analyzed by spectrophotometric, fluorescent, immunological, and molecular assays.
The results showed that açaí extract can potentially increase protein amount and enzyme activity of mitochondrial complex I, mainly through NDUFS7 and NDUFS8 overexpression.
Açaí extract was also able to decrease cell reactive oxygen species levels and lipid peroxidation.
We thus suggest açaí as a potential candidate for drug development and a possible alternative BD therapy.
American Psychological Association (APA)
Machado, Alencar Kolinski& Andreazza, Ana Cristina& da Silva, Tatiane Morgana& Boligon, Aline Augusti& do Nascimento, Vanusa& Scola, Gustavo…[et al.]. 2016. Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114468
Modern Language Association (MLA)
Machado, Alencar Kolinski…[et al.]. Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114468
American Medical Association (AMA)
Machado, Alencar Kolinski& Andreazza, Ana Cristina& da Silva, Tatiane Morgana& Boligon, Aline Augusti& do Nascimento, Vanusa& Scola, Gustavo…[et al.]. Neuroprotective Effects of Açaí (Euterpe oleracea Mart.) against Rotenone In Vitro Exposure. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114468