Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis
Joint Authors
Lozovoy, Marcell Alysson Batisti
Kallaur, Ana Paula
Costa, Neide Tomimura
Veiga Iriyoda, Tatiana Mayumi
Delongui, Francieli
Alfieri, Daniela Frizon
Amin, Ricardo Braga
Delfino, Vinicius Daher Alvares
Dichi, Isaias
Simão, Andréa Name Colado
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to evaluate the involvement of TNF-α and insulin resistance (IR) in the inflammatory process, oxidative stress, and disease activity in patients with rheumatoid arthritis (RA).
This cross-sectional study included 270 subjects (control group, n = 97 ) and RA patients ( n = 173 ).
RA patients were divided into four groups: the first group without IR and not using antitumor necrosis factor-α ( T N F - ) (G1, IR− TNF−); the second group without IR and using anti-TNF-α (G2, I R - TNF+); the third group with IR and not using anti-TNF-α (G3, IR+ T N F - ); and the fourth group with IR and using anti-TNF-α (G4, IR+ TNF+).
G3 and G4 had higher ( p < 0.05 ) advanced oxidation protein products (AOPPs) and oxidative stress index (OSI) compared to G1.
G4 group presented higher ( p < 0.05 ) AOPPs and OSI than G2.
TRAP was significantly lower in G3 compared to G1.
Plasma TNF-α levels were significantly higher in G4 and G2 compared to G1 ( p < 0.0001 ) and G3 ( p < 0.0001 and p < 0.01 , resp.).
The presence of insulin resistance was robustly associated with both oxidative stress and TNF-α levels.
More studies are warranted to verify if IR can be involved in therapeutic failure with TNF-α inhibitors.
This trial is registered with Brazilian Clinical Trials Registry Register number RBR-2jvj92.
American Psychological Association (APA)
Costa, Neide Tomimura& Veiga Iriyoda, Tatiana Mayumi& Kallaur, Ana Paula& Delongui, Francieli& Alfieri, Daniela Frizon& Lozovoy, Marcell Alysson Batisti…[et al.]. 2016. Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114480
Modern Language Association (MLA)
Costa, Neide Tomimura…[et al.]. Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114480
American Medical Association (AMA)
Costa, Neide Tomimura& Veiga Iriyoda, Tatiana Mayumi& Kallaur, Ana Paula& Delongui, Francieli& Alfieri, Daniela Frizon& Lozovoy, Marcell Alysson Batisti…[et al.]. Influence of Insulin Resistance and TNF-α on the Inflammatory Process, Oxidative Stress, and Disease Activity in Patients with Rheumatoid Arthritis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114480