Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator
Joint Authors
Jung, Junyang
Panthi, Sandesh
Chung, Hyung-Joo
Jeong, Na Young
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hydrogen sulfide (H2S) is an emerging neuromodulator that is considered to be a gasotransmitter similar to nitrogen oxide (NO) and carbon monoxide (CO).
H2S exerts universal cytoprotective effects and acts as a defense mechanism in organisms ranging from bacteria to mammals.
It is produced by the enzymes cystathionine β-synthase (CBS), cystathionine ϒ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (MST), and D-amino acid oxidase (DAO), which are also involved in tissue-specific biochemical pathways for H2S production in the human body.
H2S exerts a wide range of pathological and physiological functions in the human body, from endocrine system and cellular longevity to hepatic protection and kidney function.
Previous studies have shown that H2S plays important roles in peripheral nerve regeneration and degeneration and has significant value during Schwann cell dedifferentiation and proliferation but it is also associated with axonal degradation and the remyelination of Schwann cells.
To date, physiological and toxic levels of H2S in the human body remain unclear and most of the mechanisms of action underlying the effects of H2S have yet to be fully elucidated.
The primary purpose of this review was to provide an overview of the role of H2S in the human body and to describe its beneficial effects.
American Psychological Association (APA)
Panthi, Sandesh& Chung, Hyung-Joo& Jung, Junyang& Jeong, Na Young. 2016. Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114667
Modern Language Association (MLA)
Panthi, Sandesh…[et al.]. Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114667
American Medical Association (AMA)
Panthi, Sandesh& Chung, Hyung-Joo& Jung, Junyang& Jeong, Na Young. Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114667