Glutathione as a Biomarker in Parkinson’s Disease: Associations with Aging and Disease Severity
Joint Authors
Mischley, Laurie K.
Weiss, Noel S.
Padowski, Jeannie M.
Kavanagh, Terrance J.
White, Collin C.
Rosenfeld, Michael E.
Standish, Leanna J.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Oxidative stress contributes to Parkinson’s disease (PD) pathophysiology and progression.
The objective was to describe central and peripheral metabolites of redox metabolism and to describe correlations between glutathione (Glu) status, age, and disease severity.
Methods.
58 otherwise healthy individuals with PD were examined during a single study visit.
Descriptive statistics and scatterplots were used to evaluate normality and distribution of this cross-sectional sample.
Blood tests and magnetic resonance spectroscopy (MRS) were used to collect biologic data.
Spearman’s rank-order correlation coefficients were used to evaluate the strength and direction of the association.
The Unified PD Rating Scale (UPDRS) and the Patient-Reported Outcomes in PD (PRO-PD) were used to rate disease severity using regression analysis.
Results.
Blood measures of Glu decreased with age, although there was no age-related decline in MRS Glu.
The lower the blood Glu concentration, the more severe the UPDRS ( P = 0.02 , 95% CI: −13.96, −1.14) and the PRO-PD ( P = 0.01 , 95% CI: −0.83, −0.11) scores.
Discussion.
These data suggest whole blood Glu may have utility as a biomarker in PD.
Future studies should evaluate whether it is a modifiable risk factor for PD progression and whether Glu fortification improves PD outcomes.
American Psychological Association (APA)
Mischley, Laurie K.& Standish, Leanna J.& Weiss, Noel S.& Padowski, Jeannie M.& Kavanagh, Terrance J.& White, Collin C.…[et al.]. 2016. Glutathione as a Biomarker in Parkinson’s Disease: Associations with Aging and Disease Severity. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114764
Modern Language Association (MLA)
Mischley, Laurie K.…[et al.]. Glutathione as a Biomarker in Parkinson’s Disease: Associations with Aging and Disease Severity. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114764
American Medical Association (AMA)
Mischley, Laurie K.& Standish, Leanna J.& Weiss, Noel S.& Padowski, Jeannie M.& Kavanagh, Terrance J.& White, Collin C.…[et al.]. Glutathione as a Biomarker in Parkinson’s Disease: Associations with Aging and Disease Severity. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114764
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114764