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Alpha-Synuclein in Parkinson’s Disease: From Pathogenetic Dysfunction to Potential Clinical Application
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Parkinson’s disease is a neurodegenerative disease/synucleinopathy that develops slowly; however, there is no efficient method of early diagnosis, nor is there a cure.
Progressive dopaminergic neuronal cell loss in the substantia nigra pars compacta and widespread aggregation of the α-synuclein protein (encoded by the SNCA gene) in the form of Lewy bodies and Lewy neurites are the neuropathological hallmarks of Parkinson’s disease.
The SNCA gene has undergone gene duplications, triplications, and point mutations.
However, the specific mechanism of α-synuclein in Parkinson’s disease remains obscure.
Recent research showed that various α-synuclein oligomers, pathological aggregation, and propagation appear to be harmful in certain areas in Parkinson’s disease patients.
This review summarizes our current knowledge of the pathogenetic dysfunction of α-synuclein associated with Parkinson’s disease and highlights current approaches that seek to develop this protein as a possible diagnostic biomarker and therapeutic target.
American Psychological Association (APA)
Xu, Lingjia& Pu, Jiali. 2016. Alpha-Synuclein in Parkinson’s Disease: From Pathogenetic Dysfunction to Potential Clinical Application. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115191
Modern Language Association (MLA)
Xu, Lingjia& Pu, Jiali. Alpha-Synuclein in Parkinson’s Disease: From Pathogenetic Dysfunction to Potential Clinical Application. Parkinson’s Disease No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1115191
American Medical Association (AMA)
Xu, Lingjia& Pu, Jiali. Alpha-Synuclein in Parkinson’s Disease: From Pathogenetic Dysfunction to Potential Clinical Application. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115191