Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-l-m-tyrosine Uptake in the Locus Coeruleus
Joint Authors
Muramatsu, Shin-ichi
Ono, Sayaka Asari
Sato, Toshihiko
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Freezing of gait (FOG) is a common disorder in Parkinson’s disease (PD) and could be attributed to a reduction in brain noradrenaline.
The aim of this study was to determine the relationship between aromatic l-amino acid decarboxylase (AADC) activity in the locus coeruleus (LC) and FOG in PD using high-resolution positron emission tomography with an AADC tracer, 6-[18F]fluoro-l-m-tyrosine (FMT).
We assessed 40 patients with PD and 11 age-matched healthy individuals.
PD was diagnosed based on the UK Brain Bank criteria by two movement disorder experts.
FOG was directly observed by the clinician and assessed using a patient questionnaire.
FMT uptake in the LC, caudate, and putamen was analyzed using PMOD software on coregistered magnetic resonance images.
FOG was present in 30 patients.
The severity of FOG correlated with the decrease of FMT uptake in the LC regardless of disease duration and the severity of other motor impairments, indicating dysfunction of the noradrenergic network in FOG.
American Psychological Association (APA)
Ono, Sayaka Asari& Sato, Toshihiko& Muramatsu, Shin-ichi. 2016. Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-l-m-tyrosine Uptake in the Locus Coeruleus. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1115245
Modern Language Association (MLA)
Ono, Sayaka Asari…[et al.]. Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-l-m-tyrosine Uptake in the Locus Coeruleus. Parkinson’s Disease No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1115245
American Medical Association (AMA)
Ono, Sayaka Asari& Sato, Toshihiko& Muramatsu, Shin-ichi. Freezing of Gait in Parkinson’s Disease Is Associated with Reduced 6-[18F]Fluoro-l-m-tyrosine Uptake in the Locus Coeruleus. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1115245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115245