Outlining a Population “at Risk” of Parkinson’s Disease: Evidence from a Case-Control Study
Joint Authors
Schirinzi, Tommaso
Martella, Giuseppina
D’Elia, Alessio
Di Lazzaro, Giulia
Imbriani, Paola
Madeo, Graziella
Monaco, Leonardo
Maltese, Marta
Pisani, Antonio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The multifactorial pathogenesis of Parkinson’s Disease (PD) requires a careful identification of populations “at risk” of developing the disease.
In this case-control study we analyzed a large Italian population, in an attempt to outline general criteria to define a population “at risk” of PD.
We enrolled 300 PD patients and 300 controls, gender and age matched, from the same urban geographical area.
All subjects were interviewed on demographics, family history of PD, occupational and environmental toxicants exposure, smoking status, and alcohol consumption.
A sample of 65 patients and 65 controls also underwent serum dosing of iron, copper, mercury, and manganese by means of Inductively Coupled-Plasma-Mass-Spectrometry (ICP-MS).
Positive family history, toxicants exposure, non-current-smoker, and alcohol nonconsumer status occurred as significant risk factors in our population.
The number of concurring risk factors overlapping in the same subject impressively increased the overall risk.
No significant differences were measured in the metal serum levels.
Our findings indicate that combination of three to four concurrent PD-risk factors defines a condition “at risk” of PD.
A simple stratification, based on these questionnaires, might be of help in identifying subjects suitable for neuroprotective strategies.
American Psychological Association (APA)
Schirinzi, Tommaso& Martella, Giuseppina& D’Elia, Alessio& Di Lazzaro, Giulia& Imbriani, Paola& Madeo, Graziella…[et al.]. 2016. Outlining a Population “at Risk” of Parkinson’s Disease: Evidence from a Case-Control Study. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115284
Modern Language Association (MLA)
Schirinzi, Tommaso…[et al.]. Outlining a Population “at Risk” of Parkinson’s Disease: Evidence from a Case-Control Study. Parkinson’s Disease No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115284
American Medical Association (AMA)
Schirinzi, Tommaso& Martella, Giuseppina& D’Elia, Alessio& Di Lazzaro, Giulia& Imbriani, Paola& Madeo, Graziella…[et al.]. Outlining a Population “at Risk” of Parkinson’s Disease: Evidence from a Case-Control Study. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115284