PPARδ as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance

Abstract EN

PPARδ is a ligand-activated nuclear receptor that regulates the transcription of genes associated with proliferation, metabolism, inflammation, and immunity.

Within this transcription factor family, PPARδ is unique in that it initiates oncogenesis in a metabolic and tissue-specific context, especially in mammary epithelium, and can regulate autoimmunity in some tissues.

This review discusses its role in these processes and how it ultimately impacts breast cancer.