PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance
Joint Authors
Liu, Jia
Wang, Guang
Lu, Rui
Wang, Ying
Hu, Yanjin
Jia, Yumei
Yang, Ning
Fu, Jing
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hypertriglyceridemia is an important risk factor associated with insulin resistance and β-cell dysfunction.
This study investigated the effects of hypertriglyceridemia and fenofibrate treatment on insulin sensitivity and β-cell function in subjects with normal glucose tolerance.
A total of 1974 subjects with normal glucose tolerance were divided into the normal TG group (NTG group, n = 1 302 ) and hypertriglyceridemia group (HTG group, n = 672 ).
Next, 92 patients selected randomly from 672 patients with hypertriglyceridemia were assigned to a 24-week fenofibrate treatment.
The HTG group had increased waist circumference (WC), body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), and homeostasis model assessment of β-cell function (HOMA-β) and decreased high-density lipoprotein cholesterol (HDL-C) compared with the NTG group (all P < 0.01 ).
The 24-week fenofibrate treatment significantly decreased the WC, BMI, TG, HOMA-IR, and HOMA-β levels and increased the HDL-C levels in the patients with hypertriglyceridemia (WC, BMI, and HOMA-IR: P < 0.05 ; TG, HDL-C, and HOMA-β: P < 0.01 ).
The fenofibrate treatment significantly alleviated insulin resistance and reduced the secreting load of β-cells in the hypertriglyceridemia patients with normal glucose tolerance.
American Psychological Association (APA)
Liu, Jia& Lu, Rui& Wang, Ying& Hu, Yanjin& Jia, Yumei& Yang, Ning…[et al.]. 2016. PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance. PPAR Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115334
Modern Language Association (MLA)
Liu, Jia…[et al.]. PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance. PPAR Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115334
American Medical Association (AMA)
Liu, Jia& Lu, Rui& Wang, Ying& Hu, Yanjin& Jia, Yumei& Yang, Ning…[et al.]. PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115334