PPARγ in Bacterial Infections: A Friend or Foe?

Joint Authors

Reddy, Aravind T.
Lakshmi, Sowmya P.
Reddy, Raju C.

Source

PPAR Research

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-09-28

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

Peroxisome proliferator-activated receptor γ (PPARγ) is now recognized as an important modulator of leukocyte inflammatory responses and function.

Its immunoregulatory function has been studied in a variety of contexts, including bacterial infections of the lungs and central nervous system, sepsis, and conditions such as chronic granulomatous disease.

Although it is generally believed that PPARγ activation is beneficial for the host during bacterial infections via its anti-inflammatory and antibacterial properties, PPARγ agonists have also been shown to dampen the host immune response and in some cases exacerbate infection by promoting leukocyte apoptosis and interfering with leukocyte migration and infiltration.

In this review we discuss the role of PPARγ and its activation during bacterial infections, with focus on the potential of PPARγ agonists and perhaps antagonists as novel therapeutic modalities.

We conclude that adjustment in the dosage and timing of PPARγ agonist administration, based on the competence of host antimicrobial defenses and the extent of inflammatory response and tissue injury, is critical for achieving the essential balance between pro- and anti-inflammatory effects on the immune system.

American Psychological Association (APA)

Reddy, Aravind T.& Lakshmi, Sowmya P.& Reddy, Raju C.. 2016. PPARγ in Bacterial Infections: A Friend or Foe?. PPAR Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115352

Modern Language Association (MLA)

Reddy, Raju C.…[et al.]. PPARγ in Bacterial Infections: A Friend or Foe?. PPAR Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1115352

American Medical Association (AMA)

Reddy, Aravind T.& Lakshmi, Sowmya P.& Reddy, Raju C.. PPARγ in Bacterial Infections: A Friend or Foe?. PPAR Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1115352

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1115352