Prevalence of Antipsychotic Polypharmacy and Associated Factors among Outpatients with Schizophrenia Attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia

Joint Authors

Tesfaye, Siranesh
Debencho, Nigussie
Kisi, Teresa
Tareke, Minale

Source

Psychiatry Journal

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-01-24

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Psychology
Medicine
Psychiatry

Abstract EN

Background.

Despite recommendations by guidelines to avoid combinations of antipsychotics unless after multiple trials of antipsychotic monotherapy, it is quite a common practice to use combinations.

This practice leads to unnecessary expenses and exposes the patient to severe drug adverse effects.

Methods.

An institution based cross-sectional study was conducted from April to May 2014.

Systematic random sampling technique was used to select 423 study subjects.

Logistic regression analysis was conducted to identify associated factors of antipsychotic polypharmacy among schizophrenia outpatients.

Result.

The overall prevalence of antipsychotic polypharmacy was found to be 28.2%.

Extra pyramidal side effects (AOR = 2.80; 95% CI: 1.38, 5.71), repeated psychiatric hospitalization (AOR = 2.83; 95% CI: 1.45, 5.50), history of substance use (AOR = 2.82; 95% CI: 1.36, 5.88), longer duration of treatment (AOR = 2.10; 95% CI: 1.14, 3.87), and drug nonadherence (AOR = 1.84; 95% CI: 1.14, 2.98) were found to be significantly associated with antipsychotic polypharmacy.

Conclusion.

Prevalence of antipsychotic polypharmacy was found to be high among the current study participants.

Individuals who had extra pyramidal side effects, admission, substance use, duration of treatment, and drug nonadherence were associated with antipsychotic polypharmacy.

American Psychological Association (APA)

Tesfaye, Siranesh& Debencho, Nigussie& Kisi, Teresa& Tareke, Minale. 2016. Prevalence of Antipsychotic Polypharmacy and Associated Factors among Outpatients with Schizophrenia Attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. Psychiatry Journal،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115622

Modern Language Association (MLA)

Tesfaye, Siranesh…[et al.]. Prevalence of Antipsychotic Polypharmacy and Associated Factors among Outpatients with Schizophrenia Attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. Psychiatry Journal No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1115622

American Medical Association (AMA)

Tesfaye, Siranesh& Debencho, Nigussie& Kisi, Teresa& Tareke, Minale. Prevalence of Antipsychotic Polypharmacy and Associated Factors among Outpatients with Schizophrenia Attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. Psychiatry Journal. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115622

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1115622