Ewing’s Sarcoma as a Second Malignancy in Long-Term Survivors of Childhood Hematologic Malignancies
Joint Authors
Wolpert, Fabian
Grotzer, Michael A.
Zimmermann, Dieter
Rushing, Elisabeth
Bode-Lesniewska, Beata
Niggli, Felix
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Modern multimodal treatment has significantly increased survival for patients affected by hematologic malignancies, especially in childhood.
Following remission, however, the risk of developing a further malignancy is an important issue.
The long-term estimated risk of developing a sarcoma as a secondary malignancy is increased severalfold in comparison to the general population.
Ewing’s sarcoma family encompasses a group of highly aggressive, undifferentiated, intra- and extraosseous, mesenchymal tumors, caused by several types of translocations usually involving the EWSR1 gene.
Translocation associated sarcomas, such as Ewing sarcoma, are only rarely encountered as therapy associated secondary tumors.
We describe the clinical course and management of three patients from a single institution with Ewing’s sarcoma that followed successfully treated lymphoblastic T-cell leukemia or non-Hodgkin lymphoma.
The literature on secondary Ewing’s sarcoma is summarized and possible pathogenic mechanisms are critically discussed.
American Psychological Association (APA)
Wolpert, Fabian& Grotzer, Michael A.& Niggli, Felix& Zimmermann, Dieter& Rushing, Elisabeth& Bode-Lesniewska, Beata. 2016. Ewing’s Sarcoma as a Second Malignancy in Long-Term Survivors of Childhood Hematologic Malignancies. Complexity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115770
Modern Language Association (MLA)
Wolpert, Fabian…[et al.]. Ewing’s Sarcoma as a Second Malignancy in Long-Term Survivors of Childhood Hematologic Malignancies. Complexity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1115770
American Medical Association (AMA)
Wolpert, Fabian& Grotzer, Michael A.& Niggli, Felix& Zimmermann, Dieter& Rushing, Elisabeth& Bode-Lesniewska, Beata. Ewing’s Sarcoma as a Second Malignancy in Long-Term Survivors of Childhood Hematologic Malignancies. Complexity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115770