Galectin-1, -4, and -7 Were Associated with High Activity of Disease in Patients with Rheumatoid Arthritis
Joint Authors
Pitta, Ivan da Rocha
Pereira, Michelly Cristiny
Marques, Claudia Diniz Lopes
Duarte, Angela Luzia Branco Pinto
Gonçalves, Rafaela Silva Guimarães
Vilar, Kamila de Melo
Rêgo, Moacyr Jesus Barreto de Melo
da Rocha Junior, Laurindo Ferreira
Pitta, Maira Galdino da Rocha
Dantas, Andréa Tavares
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Due to the variety of functions that galectins (Gal) possess, it is clear that they participate in the pathogenesis of rheumatoid arthritis (RA).
Although some studies demonstrate their functions, there is still no correlation with the clinical data of the disease, having the physiological meaning still unknown.
Objectives.
To compare serum levels of Gal-1, -4, and -7 in patients with RA and healthy controls and to correlate them with clinical parameters.
Methods.
Serum samples were collected from patients with RA and healthy donors to determine the serum levels of Gal-1, -4, and -7.
Results.
Serum levels of Gal-1, -4, and -7 were significantly higher in RA patients compared to controls.
We evaluated disease activity (CDAI) with serum levels of galectins and found that patients who were high in disease activity had high levels of galectin compared to the moderate activity group.
Galectin-4 had higher levels in patients who were in high activity when compared to the group in remission or low activity.
Evaluating the activity of the individual disease (DAS28), patients in high individual activity had high levels of Gal-4 when compared to the group in remission or low activity.
We also found an association between positive rheumatoid factor and Gal-1 and Gal-4 levels.
Conclusion.
Our results show for the first time the relationship between serum levels of galectin and the clinical parameters of patients with RA.
Demonstrating their role in pathogenesis, new studies with galectins are needed to assess how they function as a biomarker in RA.
American Psychological Association (APA)
Vilar, Kamila de Melo& Pereira, Michelly Cristiny& Dantas, Andréa Tavares& Rêgo, Moacyr Jesus Barreto de Melo& Pitta, Ivan da Rocha& Marques, Claudia Diniz Lopes…[et al.]. 2019. Galectin-1, -4, and -7 Were Associated with High Activity of Disease in Patients with Rheumatoid Arthritis. Autoimmune Diseases،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1117930
Modern Language Association (MLA)
Vilar, Kamila de Melo…[et al.]. Galectin-1, -4, and -7 Were Associated with High Activity of Disease in Patients with Rheumatoid Arthritis. Autoimmune Diseases No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1117930
American Medical Association (AMA)
Vilar, Kamila de Melo& Pereira, Michelly Cristiny& Dantas, Andréa Tavares& Rêgo, Moacyr Jesus Barreto de Melo& Pitta, Ivan da Rocha& Marques, Claudia Diniz Lopes…[et al.]. Galectin-1, -4, and -7 Were Associated with High Activity of Disease in Patients with Rheumatoid Arthritis. Autoimmune Diseases. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1117930
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117930