Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents
Joint Authors
Bellare, Jayesh
Ghosh, Sougata
Jamdade, Dhiraj A.
Rajpali, Dishantsingh
Joshi, Komal A.
Kulkarni, Anuja S.
Shinde, Vaishali S.
Babiya, Kaushik R.
Kitture, Rohini
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Rapid, eco-friendly, and cost-effective one-pot synthesis of copper nanoparticles is reported here using medicinal plants like Gnidia glauca and Plumbago zeylanica.
Aqueous extracts of flower, leaf, and stem of G.
glauca and leaves of P.
zeylanica were prepared which could effectively reduce Cu2+ ions to CuNPs within 5 h at 100°C which were further characterized using UV-visible spectroscopy, field emission scanning electron microscopy, high-resolution transmission electron microscopy, energy dispersive spectroscopy, dynamic light scattering, X-ray diffraction, and Fourier-transform infrared spectroscopy.
Further, the CuNPs were checked for antidiabetic activity using porcine pancreatic α-amylase and α-glucosidase inhibition followed by evaluation of mechanism using circular dichroism spectroscopy.
CuNPs were found to be predominantly spherical in nature with a diameter ranging from 1 to 5 nm.
The phenolics and flavonoids in the extracts might play a critical role in the synthesis and stabilization process.
Significant change in the peak at ∼1095 cm−1 corresponding to C-O-C bond in ether was observed.
CuNPs could inhibit porcine pancreatic α-amylase up to 30% to 50%, while they exhibited a more significant inhibition of α-glucosidase from 70% to 88%.
The mechanism of enzyme inhibition was attributed due to the conformational change owing to drastic alteration of secondary structure by CuNPs.
This is the first study of its kind that provides a strong scientific rationale that phytogenic CuNPs synthesized using G.
glauca and P.
zeylanica can be considered to develop candidate antidiabetic nanomedicine.
American Psychological Association (APA)
Jamdade, Dhiraj A.& Rajpali, Dishantsingh& Joshi, Komal A.& Kitture, Rohini& Kulkarni, Anuja S.& Shinde, Vaishali S.…[et al.]. 2019. Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1121834
Modern Language Association (MLA)
Jamdade, Dhiraj A.…[et al.]. Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents. Advances in Pharmacological and Pharmaceutical Sciences No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1121834
American Medical Association (AMA)
Jamdade, Dhiraj A.& Rajpali, Dishantsingh& Joshi, Komal A.& Kitture, Rohini& Kulkarni, Anuja S.& Shinde, Vaishali S.…[et al.]. Gnidia glauca- and Plumbago zeylanica-Mediated Synthesis of Novel Copper Nanoparticles as Promising Antidiabetic Agents. Advances in Pharmacological and Pharmaceutical Sciences. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1121834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1121834