Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes
Joint Authors
Perera, Inoka C.
Perera, Theshini
Abeydeera, Nalin
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Four Zn(II) complexes containing a pyridyl triazine core (L1 = 3-(2-pyridyl)-5,6-di(2-furyl)-1,2,4-triazine-5′,5″-disulfonic acid disodium salt and L2 = 3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine-4′,4″-disulfonic acid sodium salt) were synthesized, and their chemical formulas were finalized as [Zn(L1)Cl2]·5H2O·ZnCl2 (1), [Zn(L1)2Cl2]·4H2O·2CH3OH (2), [Zn(L2)Cl2]·3H2O·CH3OH (3), and [Zn(L2)2Cl2] (4).
The synthesized complexes are water soluble, making them good candidates for biological applications.
All four complexes have been characterized by elemental analysis and 1H NMR, IR, and UV-Vis spectroscopy.
The IR stretching frequency of N=N and C=N bonds of complexes 1–4 have shifted to lower frequencies in comparison with free ligands, and a bathochromic shift was observed in UV-Vis spectra of all four complexes.
The binding studies of ligands and complexes 1–4 with bovine serum albumin (BSA) resulted binding constants (Kb) of 3.09 × 104 M−1, 12.30 × 104 M−1, and 16.84 × 104 M−1 for ferene, complex 1, and complex 2, respectively, indicating potent serum distribution via albumins.
American Psychological Association (APA)
Abeydeera, Nalin& Perera, Inoka C.& Perera, Theshini. 2018. Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1123197
Modern Language Association (MLA)
Abeydeera, Nalin…[et al.]. Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1123197
American Medical Association (AMA)
Abeydeera, Nalin& Perera, Inoka C.& Perera, Theshini. Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1123197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123197