Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years

Joint Authors

Xu, Jiancheng
Guo, Wenjia
Zhou, Qi
Jia, Yanan

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-12-23

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Age- and sex-specific reference intervals (RIs) for myocardial enzyme activity of children and adolescents are not available in China.

Our study aimed to establish age- and gender-related RIs for AST, LDH, CK, and CKMB activity in healthy Chinese Han population aged 1∼<18 years.

Healthy Han children and adolescents (n = 6322, 1∼<18 years old) were assessed from completed questionnaires and defined criteria from communities and schools in 5 administrative districts of Jilin Province from September 2017 to December 2018.

Measurements of AST, LDH, CK, and CKMB activity were performed on the VITROS 5600 Integrated System.

Percentiles of enzyme activity were completed by LMS.

RIs were established by Medcalc according to the EP28-A3c guidelines issued by the Clinical and Laboratory Standards Institute.

AST declined rapidly during 1∼<6 years and had been subsided during 11∼<18 years, though LDH decreased at a steady rate.

CK activity stabilized while CKMB showed a downward trend.

Sex differences started after age 12 when males presented higher results.

There were significant differences comparing with domestic and other countries’ experiments which applied similar methodologies.

Enzymes were associated with age and sex, while age had greater impact.

We established age- and sex-specific RIs of serum AST, LDH, CK, and CKMB activities for Chinese children and adolescents using the VITROS 5600 Integrated System for the first time.

These data will lay the groundwork for the next horizon in pediatric RIs as well as improve test result interpretation for pediatric illness.

American Psychological Association (APA)

Guo, Wenjia& Zhou, Qi& Jia, Yanan& Xu, Jiancheng. 2019. Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123612

Modern Language Association (MLA)

Guo, Wenjia…[et al.]. Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1123612

American Medical Association (AMA)

Guo, Wenjia& Zhou, Qi& Jia, Yanan& Xu, Jiancheng. Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1123612

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1123612