Hyposmia as a Predictive Marker of Parkinson’s Disease: A Systematic Review and Meta-Analysis
Joint Authors
Li, Feng
Sui, Xin
Zhou, Changli
Li, Jinwei
Chen, Lei
Yang, Xige
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Hyposmia is one of the most common and best-characterized conditions that is also one of the first nonmotor features of Parkinson’s disease (PD).
The association of hyposmia with PD is widely accepted; however the likelihood of developing PD is unclear.
Our meta-analysis aimed to investigate the risk of PD in individuals with hyposmia.
Methods.
Prospective studies on humans published before December 4th, 2018, were searched for in PubMed, Embase, Web of Science, and Cochrane Library databases.
Two independent reviewers screened studies for inclusion and extracted data.
We assessed the quality of studies using the Newcastle–Ottawa Scale and pooled data for analysis using random-effects models.
Results.
Of the 1774 studies retrieved, seven met the inclusion criteria for this review.
A total of 3272 hyposmia and 176 PD events were reported over follow-up periods ranging from 3 to 17 years.
Hyposmia was associated with a 3.84-fold risk of developing PD (pooled relative risk: 3.84, 95% CI 2.12−6.95).
Subgroup analyses identified few differences between different hyposmia assessment methodologies and follow-up periods.
Conclusions.
Our findings suggest that deficiencies in olfaction are associated with an increased risk of developing PD.
Future studies are needed to investigate whether hyposmia is a promising and feasible biomarker for the early diagnosis of PD.
American Psychological Association (APA)
Sui, Xin& Zhou, Changli& Li, Jinwei& Chen, Lei& Yang, Xige& Li, Feng. 2019. Hyposmia as a Predictive Marker of Parkinson’s Disease: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124819
Modern Language Association (MLA)
Sui, Xin…[et al.]. Hyposmia as a Predictive Marker of Parkinson’s Disease: A Systematic Review and Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1124819
American Medical Association (AMA)
Sui, Xin& Zhou, Changli& Li, Jinwei& Chen, Lei& Yang, Xige& Li, Feng. Hyposmia as a Predictive Marker of Parkinson’s Disease: A Systematic Review and Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1124819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1124819