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Hepatitis B Virus X Protein-Induced RORγ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma
Joint Authors
Huang, Yu
Liang, Huasheng
He, Chuanxiong
Peng, Fang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Aberrant expression of RORγ is implicated in cancer development.
A previous study identified that RORγ functions as a tumor promoter to drive hepatocellular carcinoma (HCC) growth.
However, its expression and significance in HCC remain unclear.
The central finding of this work is that RORγ was overexpressed in HCC due to its dysfunction of promoter methylation, and hepatitis B virus X protein (HBx) can remarkably induce the expression of RORγ in hepatocellular carcinoma through enhancing the transcriptional function.
Also, the HBx-induced RORγ could promote the migration and proliferation of hepatoma cells.
Hence, these results suggest that RORγ was an important regulator in HCC, and our finding provides new insights into the significance of RORγ in HCC.
American Psychological Association (APA)
Huang, Yu& Liang, Huasheng& He, Chuanxiong& Peng, Fang. 2019. Hepatitis B Virus X Protein-Induced RORγ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1126013
Modern Language Association (MLA)
Huang, Yu…[et al.]. Hepatitis B Virus X Protein-Induced RORγ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1126013
American Medical Association (AMA)
Huang, Yu& Liang, Huasheng& He, Chuanxiong& Peng, Fang. Hepatitis B Virus X Protein-Induced RORγ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1126013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126013