Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis
Joint Authors
Chen, Hanwei
Liang, Jianye
Song, Xiubao
Xiao, Zeyu
Shi, Changzheng
Luo, Liangping
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rationale and Objectives.
To investigate the utility of intravoxel incoherent motion MRI (IVIM-MRI) and R2⁎ mapping in diagnosing early stage liver fibrosis in a radiation-induced rat model.
Materials and Methods.
Thirty rats were randomly divided into three groups with 10 rats in each group.
Liver fibrosis was induced by exposure of right lobe of liver in each animal to 20 Gy of radiation.
MRI examination was conducted at baseline, one month, two months, and three months after radiation using T1WI, T2WI, IVIM-DWI, and R2⁎ sequences.
The pathological examination included hematoxylin eosin, masson trichrome, and prussian blue staining.
D, D⁎, f, and R2⁎ values were measured in both left and right lobes for quantitative analysis.
Results.
Regarding the surviving 23 rats, eight rats were diagnosed with stage F0, ten with stage F1, and five with stage F2 liver fibrosis using METAVIR Scores.
The D values of right lobes decreased (P<0.05), and R2⁎ values increased (P<0.01) significantly as fibrosis levels increased.
But there was no statistical difference in D⁎ (P=0.970) and f values (P=0.079).
R2⁎ value showed a strong positive correlation (r=0.819, P<0.001), while D value showed a negative correlation with fibrosis stages (r=-0.424, P<0.001).
D⁎ (r=0.029, P=0.744) and f values (r=-0.055, P=0.536) were poorly correlated with fibrosis levels.
Conclusion.
IVIM-MRI and R2⁎ mapping are useful techniques for evaluating the severity of liver fibrosis in a radiation-induced rat model, and R2⁎ value is the most sensitive parameter in detecting early stage fibrosis.
American Psychological Association (APA)
Liang, Jianye& Song, Xiubao& Xiao, Zeyu& Chen, Hanwei& Shi, Changzheng& Luo, Liangping. 2018. Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126842
Modern Language Association (MLA)
Liang, Jianye…[et al.]. Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126842
American Medical Association (AMA)
Liang, Jianye& Song, Xiubao& Xiao, Zeyu& Chen, Hanwei& Shi, Changzheng& Luo, Liangping. Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126842
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1126842