Association of Serum PSPREG Iα with Renal Function in Pregnant Women
Joint Authors
Zhu, Xiangyun
Dong, Beibei
Reding, Theresia
Peng, Youfan
Lin, Hao
Zhi, Mengmeng
Han, Manman
Graf, Rolf
Li, Ling
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pancreatic stone protein/regenerating protein Iα (PSP/REG Iα) is a secretory protein produced in the pancreas, but its expression has also been observed in the kidney.
It may be associated with kidney dysfunction.
This study investigates the possible association between PSP/REG Iα and kidney function in pregnant women.
Serum PSP/REG Iα levels were measured by a specific ELISA enzyme-linked immunosorbent assay.
Maternal information and clinical and biochemical parameters were collected.
Estimated glomerular filtration rate (eGFR) was calculated for all individuals to evaluate their renal function.
Spearman’s correlation and multiple linear regression analyses were performed to assess the associations between PSP/REG Iα and eGFR, serum creatinine (Cr), blood urea nitrogen (BUN), and uric acid (UA).
A total of 595 pregnant women were enrolled in the study.
Participants with mildly reduced eGFR had higher PSP/REG Iα levels [50.49 (35.02, 58.64)] than in the general population [26.84 (21.02, 33.07)] (p < 0.001).
Included participants were stratified into PSP/REG Iα quartiles; significant differences were observed in the levels of eGFR, serum Cr, BUN, and UA.
PSP/REG Iα was negatively correlated with eGFR (r = −0.402, p < 0.001) and positively associated with serum Cr (r = 0.468, p < 0.001), BUN (r = 0.166, p < 0.001), and UA (r = 0.207, p < 0.001).
The linear regression analysis indicated that PSP/REG Iα was associated with UA, BUN, and eGFR.
High PSP/REG Iα concentrations were closely associated with renal dysfunction in pregnant women.
Our study provides clinical evidence that serum PSP/REG Iα levels could be a novel biomarker for assessment of renal function in pregnant women.
American Psychological Association (APA)
Zhu, Xiangyun& Dong, Beibei& Reding, Theresia& Peng, Youfan& Lin, Hao& Zhi, Mengmeng…[et al.]. 2019. Association of Serum PSPREG Iα with Renal Function in Pregnant Women. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1127044
Modern Language Association (MLA)
Zhu, Xiangyun…[et al.]. Association of Serum PSPREG Iα with Renal Function in Pregnant Women. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1127044
American Medical Association (AMA)
Zhu, Xiangyun& Dong, Beibei& Reding, Theresia& Peng, Youfan& Lin, Hao& Zhi, Mengmeng…[et al.]. Association of Serum PSPREG Iα with Renal Function in Pregnant Women. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1127044
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127044