The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis
Joint Authors
Zhu, Shanshan
Wang, Yuhui
Luo, Fei
Liu, Jie
Xiu, Liangchang
Qin, Jiheng
Wang, Tao
Yu, Na
Wu, Hongfu
Zou, Tangbin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The relationship between vitamin D level and NAFLD has not been investigated in children and adolescents.
We performed a meta-analysis of published observational studies to assess this association between vitamin D levels (measured as serum 25-hydroxy vitamin D [25(OH)D]) and NAFLD in this age group.
Methods.
Relevant studies conducted before May 20, 2018, were identified from the following electronic databases: PubMed, the Cochrane Library, Embase, and the Chinese CNKI databases.
The quality of the included studies was evaluated using the Newcastle Ottawa Scale, and associations between vitamin D levels and NAFLD were estimated using standardised mean differences (SMD) and 95% confidence interval (CI).
Subgroup and sensitivity analysis were used to identify sources of heterogeneity, and publication bias was evaluated using funnel plots.
Results.
Eight articles were included in this meta-analysis.
A significant difference was observed between low 25(OH)D levels and NAFLD in children and adolescents (SMD = -0.59, 95%CI = -0.98, -0.20, P < 0.01).
Subgroup analysis revealed no differences in the study type, geographic location, BMI, and age subgroups.
Conclusions.
Low vitamin D levels were associated with NAFLD in children and adolescents.
American Psychological Association (APA)
Zhu, Shanshan& Wang, Yuhui& Luo, Fei& Liu, Jie& Xiu, Liangchang& Qin, Jiheng…[et al.]. 2019. The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis. BioMed Research International،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127508
Modern Language Association (MLA)
Zhu, Shanshan…[et al.]. The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis. BioMed Research International No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1127508
American Medical Association (AMA)
Zhu, Shanshan& Wang, Yuhui& Luo, Fei& Liu, Jie& Xiu, Liangchang& Qin, Jiheng…[et al.]. The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1127508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127508