Magnesium Enhances Osteogenesis of BMSCs by Tuning Osteoimmunomodulation
Joint Authors
Zhang, Xufang
Chen, Qingpiao
Mao, Xueli
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In the process of bone tissue engineering, the osteoimmunomodulatory property of biomaterials is very important for osteogenic differentiation of stem cells, which determines the outcome of bone regeneration.
Magnesium (Mg) is a biodegradable, biocompatible metal that has osteoconductive properties and has been regarded as a promising bone biomaterial.
However, the high degradation rate of Mg leads to excessive inflammation, thereby restricting its application in bone tissue engineering.
Importantly, different coatings or magnesium alloys have been utilized to lower the rate of degradation.
In fact, a prior study proved that β-TCP coating of Mg scaffolds can modulate the osteoimmunomodulatory properties of Mg-based biomaterials and create a favorable immune microenvironment for osteogenesis.
However, the osteoimmunomodulatory properties of Mg ions themselves have not been explored yet.
In this study, the osteoimmunomodulatory properties of Mg ions with involvement of macrophages and bone marrow stem cells (BMSCs) were systematically investigated.
Microscale Mg ions (100 mg/L) were found to possess osteoimmunomodulatory properties that favor bone formation.
Specifically, microscale Mg ions induced M2 phenotype changes of macrophages and the release of anti-inflammatory cytokines by inhibiting the TLR-NF-κB signaling pathway.
Microscale Mg ions also stimulated the expression of osteoinductive molecules in macrophages while Mg ions/macrophage-conditioned medium promoted osteogenesis of BMSCs through the BMP/SMAD signaling pathway.
These findings indicate that manipulating Mg ion concentration can endow the Mg biomaterial with favorable osteoimmunomodulatory properties, thereby providing fundamental evidence for improving and modifying the effect of Mg-based bone biomaterials.
American Psychological Association (APA)
Zhang, Xufang& Chen, Qingpiao& Mao, Xueli. 2019. Magnesium Enhances Osteogenesis of BMSCs by Tuning Osteoimmunomodulation. BioMed Research International،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1127611
Modern Language Association (MLA)
Zhang, Xufang…[et al.]. Magnesium Enhances Osteogenesis of BMSCs by Tuning Osteoimmunomodulation. BioMed Research International No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1127611
American Medical Association (AMA)
Zhang, Xufang& Chen, Qingpiao& Mao, Xueli. Magnesium Enhances Osteogenesis of BMSCs by Tuning Osteoimmunomodulation. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1127611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127611