Dysbiosis and Variation in Predicted Functions of the Granulation Tissue Microbiome in HPV Positive and Negative Severe Chronic Periodontitis
Joint Authors
Chowdhry, Rebecca
Singh, Neetu
Sahu, Dinesh Kumar
Tripathi, Ratnesh Kumar
Mishra, Archana
Singh, Anjana
Kant, Ravi
Mukerjee, Indrashis
Lal, Nand
Bhatt, Madan Lal Brahma
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Retrospective analysis has already shown correlation between severe Chronic Periodontitis (CP) cases with human papiloma virus (HPV).
Hence, we aimed to explore deep-seated infected granulation tissue removed during periodontal flap surgery procedures for residential bacterial species between HPV+ and HVP- CP cases, which may serve as good predisposition marker for oral cancer.
All CP-granulation samples showed the prominence of Firmicutes, Proteobacteria, and Bacteroidetes phyla with an abundance of gram negative anaerobes, except Streptococcus.
In Beta diversity nonmetric multidimensional scaling plot, the random distribution of species was observed between HPV+ and HPV- CP granulation-samples.
However, an abundance of Capnocytophaga ochracea was observed in HPV+ CP samples (p<0.05), while Porphyromonas endodontalis, Macellibacteroides fermentas, Treponema phagedenis, and Campylobacter rectus species were highly abundant in HPV- CP samples (p<0.05).
The differential species richness leads altered functions related to mismatch-repair and nucleotide excision-repair and cytoskeleton-proteins.
Hence, differential abundance of gram negative bacterial species between HPV+ and HPV- granulation-samples under anaerobic conditions may release virulence factors which may alter pathways favouring carcinogenesis.
Hence, these species may serve as good predisposition marker for oral-cancer.
American Psychological Association (APA)
Chowdhry, Rebecca& Singh, Neetu& Sahu, Dinesh Kumar& Tripathi, Ratnesh Kumar& Mishra, Archana& Singh, Anjana…[et al.]. 2019. Dysbiosis and Variation in Predicted Functions of the Granulation Tissue Microbiome in HPV Positive and Negative Severe Chronic Periodontitis. BioMed Research International،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127758
Modern Language Association (MLA)
Chowdhry, Rebecca…[et al.]. Dysbiosis and Variation in Predicted Functions of the Granulation Tissue Microbiome in HPV Positive and Negative Severe Chronic Periodontitis. BioMed Research International No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1127758
American Medical Association (AMA)
Chowdhry, Rebecca& Singh, Neetu& Sahu, Dinesh Kumar& Tripathi, Ratnesh Kumar& Mishra, Archana& Singh, Anjana…[et al.]. Dysbiosis and Variation in Predicted Functions of the Granulation Tissue Microbiome in HPV Positive and Negative Severe Chronic Periodontitis. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1127758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127758