Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To explore the association between the acquisition process in the Y-maze and H-2 class II polymorphisms in mice.
Methods.
Mice were trained for 5 consecutive days in the Y-maze.
The value of the slope of the latent period was considered an indication for the acquisition process.
A slope < 0 indicated learning during the training and a slope > 0 indicated no learning.
The H-2 polymorphism was determined with PCR amplification, and the correlation between the alleles and the acquisition process was analyzed.
Results.
The overall percentage of mice that learned was 46.1%.
The percentage of mice that had learned with MudoEb5 (37.9%) was significantly lower than that of mice without MudoEb5 (61.1%; P < 0.05).
The percentage of mice that had learned with MudoEb7 (26.1%) was significantly lower than that of mice without MudoEb7 (51.9%; P < 0.05).
Conclusions.
The major histocompatibility complex (MHC) and other alleles may be involved in the acquisition process.
There may be a biological basis for learning in mice.
American Psychological Association (APA)
Ru, Ming& Liu, Hui. 2018. Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1127886
Modern Language Association (MLA)
Ru, Ming& Liu, Hui. Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1127886
American Medical Association (AMA)
Ru, Ming& Liu, Hui. Association between Y-Maze Acquisition Learning and Major Histocompatibility Complex Class II Polymorphisms in Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1127886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1127886