Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16

Joint Authors

Wu, Chun-Yu
Cheng, Ya-Jung
Hung, Ming-Hui
Lin, I-Ju
Chan, Kuang-Cheng
Sun, Wei-Zen

Source

BioMed Research International

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-04-11

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Background.

Acute respiratory distress syndrome (ARDS) after living-donor liver transplantation (LDLT) is not uncommon, but it lacks the biomarkers for early detection.

Club cell protein 16 (CC16), high-motility group box 1 protein (HMGB1), interleukin-1β (IL-1β), and IL-10 have been reported as relevant to the development of ARDS.

However, they have not been investigated during LDLT.

Methods.

Seventy-three consecutive recipients undergoing LDLT were enrolled and received the same perioperative care plan.

Perioperative serum CC16, HMGB1, IL-1β, and IL-10 levels were measured at the pretransplant state, 30 minutes after reperfusion, postoperative day 1 (POD1), and POD3.

ARDS was diagnosed according to the 2012 Berlin definition.

Results.

Of the 73 recipients, 13 developed ARDS with significantly longer durations of mechanical ventilation and intensive care unit stay.

Serum CC16 levels on POD1 increased significantly from the pretransplant state in the ARDS group but not in the non-ARDS group.

Pretransplant serum CC16 levels were also higher in the ARDS group.

The area under the receiver operating characteristic curves for POD1 serum CC16 levels used to discriminate ARDS was 0.803 (95% confidence interval: 0.679 to 0.895; p < 0.001).

By comparison, HMGB1, IL-1β, and IL-10 were not associated with ARDS after LDLT.

Conclusion.

The higher pretransplant serum CC16 level and its increased level on POD1 were associated with the development of early ARDS after LDLT.

This trial is registered with NCT01936545, 27 August 2013.

American Psychological Association (APA)

Wu, Chun-Yu& Cheng, Ya-Jung& Hung, Ming-Hui& Lin, I-Ju& Sun, Wei-Zen& Chan, Kuang-Cheng. 2019. Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. BioMed Research International،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1128187

Modern Language Association (MLA)

Wu, Chun-Yu…[et al.]. Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. BioMed Research International No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1128187

American Medical Association (AMA)

Wu, Chun-Yu& Cheng, Ya-Jung& Hung, Ming-Hui& Lin, I-Ju& Sun, Wei-Zen& Chan, Kuang-Cheng. Association between Early Acute Respiratory Distress Syndrome after Living-Donor Liver Transplantation and Perioperative Serum Biomarkers: The Role of Club Cell Protein 16. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1128187

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1128187