Evaluation of Cytochalasin B-Induced Membrane Vesicles Fusion Specificity with Target Cells
Joint Authors
Rizvanov, Albert A.
Gomzikova, Marina
Kletukhina, Sevindzh
Kurbangaleeva, Sirina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Extracellular vesicles (EV) represent a promising vector system for biomolecules and drug delivery due to their natural origin and participation in intercellular communication.
As the quantity of EVs is limited, it was proposed to induce the release of membrane vesicles from the surface of human cells by treatment with cytochalasin B.
Cytochalasin B-induced membrane vesicles (CIMVs) were successfully tested as a vector for delivery of dye, nanoparticles, and a chemotherapeutic.
However, it remained unclear whether CIMVs possess fusion specificity with target cells and thus might be used for more targeted delivery of therapeutics.
To answer this question, CIMVs were obtained from human prostate cancer PC3 cells.
The diameter of obtained CIMVs was 962,13 ± 140,6 nm.
We found that there is no statistically significant preference in PC3 CIMVs fusion with target cells of the same type.
According to our observations, the greatest impact on CIMVs entry into target cells is by the heterophilic interaction of CIMV membrane receptors with the surface proteins of target cells.
American Psychological Association (APA)
Gomzikova, Marina& Kletukhina, Sevindzh& Kurbangaleeva, Sirina& Rizvanov, Albert A.. 2018. Evaluation of Cytochalasin B-Induced Membrane Vesicles Fusion Specificity with Target Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128238
Modern Language Association (MLA)
Gomzikova, Marina…[et al.]. Evaluation of Cytochalasin B-Induced Membrane Vesicles Fusion Specificity with Target Cells. BioMed Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1128238
American Medical Association (AMA)
Gomzikova, Marina& Kletukhina, Sevindzh& Kurbangaleeva, Sirina& Rizvanov, Albert A.. Evaluation of Cytochalasin B-Induced Membrane Vesicles Fusion Specificity with Target Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1128238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1128238