Novel Compliant Scaffold with Specific Design for Venous System: Results of a Porcine Model Study

Joint Authors

Veroux, Pierfrancesco
Secchiero, Paola
Veroux, Massimiliano
Scanziani, Eugenio
Virgilio, Carla
Zani, Davide Danilo
Ravasio, Giuliano
Ardita, Vincenzo
Zamboni, Paolo
Giaquinta, Alessia

Source

BioMed Research International

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-01-31

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Background.

Stenting has become the first-line treatment of obstructive venous disease because of poor results of balloon angioplasty.

This preclinical study aimed to investigate the safety and efficacy profile of a novel compliant venous scaffold (CVS) denominated Petalo CVS, specifically designed for venous diseases.

Materials and Methods.

Twelve healthy pigs weighing 90 kg were used to test Petalo CVS.

The devices were implanted into the internal jugular veins (IJVs) using a femoral vein percutaneous approach.

The safety profile including the success rate of device releasing, anchoring, and positioning was evaluated immediately.

Fracture, migration, primary patency, and endothelial response were assessed at 1, 2, 3, and 6 months after the study procedure.

Results.

A total of 32 devices were successfully released in both IJVs.

No procedure- or device-related complications were reported, and all pigs successfully completed the different scheduled follow-up periods.

The primary patency rate was 100%, and no fracture or migration of the device into the brachiocephalic trunk was reported.

Histological examination revealed only minimal lesions with minimal or absent inflammatory reaction surrounding the incorporated metallic rods.

Conclusions.

This porcine model study showed a promising safety and efficacy profile of Petalo CVS, a novel endovenous device based on specific concepts.

American Psychological Association (APA)

Veroux, Pierfrancesco& Giaquinta, Alessia& Virgilio, Carla& Zani, Davide Danilo& Ravasio, Giuliano& Ardita, Vincenzo…[et al.]. 2018. Novel Compliant Scaffold with Specific Design for Venous System: Results of a Porcine Model Study. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128393

Modern Language Association (MLA)

Veroux, Pierfrancesco…[et al.]. Novel Compliant Scaffold with Specific Design for Venous System: Results of a Porcine Model Study. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128393

American Medical Association (AMA)

Veroux, Pierfrancesco& Giaquinta, Alessia& Virgilio, Carla& Zani, Davide Danilo& Ravasio, Giuliano& Ardita, Vincenzo…[et al.]. Novel Compliant Scaffold with Specific Design for Venous System: Results of a Porcine Model Study. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128393

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1128393