Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling
Joint Authors
Jia, Zhenquan
Yang, Manli
Ahmed, Hassan
Wu, Weidong
Jiang, Bijie
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Atmospheric pollution has been a principal topic recently in the scientific and political community due to its role and impact on human and ecological health.
9,10-phenanthrenequinone (9,10-PQ) is a quinone molecule found in air pollution abundantly in the diesel exhaust particles (DEP).
This compound has studied extensively and has been shown to develop cytotoxic effects both in vitro and in vivo.
9, 10-PQ has been proposed to play a critical role in the development of cytotoxicity via generation of reactive oxygen species (ROS) through redox cycling.
This compound also reduces expression of glutathione (GSH), which is critical in Phase II detoxification reactions.
Understanding the underlying cellular mechanisms involved in cytotoxicity can allow for the development of therapeutics designed to target specific molecules significantly involved in the 9,10-PQ-induced ROS toxicity.
This review highlights the developments in the understanding of the cytotoxic effects of 9, 10-PQ with special emphasis on the possible mechanisms involved.
American Psychological Association (APA)
Yang, Manli& Ahmed, Hassan& Wu, Weidong& Jiang, Bijie& Jia, Zhenquan. 2018. Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling. BioMed Research International،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129836
Modern Language Association (MLA)
Yang, Manli…[et al.]. Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling. BioMed Research International No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1129836
American Medical Association (AMA)
Yang, Manli& Ahmed, Hassan& Wu, Weidong& Jiang, Bijie& Jia, Zhenquan. Cytotoxicity of Air Pollutant 9,10-Phenanthrenequinone: Role of Reactive Oxygen Species and Redox Signaling. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1129836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1129836