Self-Collected Specimens Revealed a Higher Vaccine- and Non-Vaccine-Type Human Papillomavirus Prevalences in a Cross-Sectional Study in Akuse
Joint Authors
Awua, Adolf K.
Severini, Alberto
Wiredu, Edwin K.
Afari, Edwin A.
Zubach, Vanessa A.
Adanu, Richard M. K.
Source
Advances in Preventive Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Population-specific epidemiologic data on human Papillomavirus infection, which are limited in most of the SubSaharan African countries, are necessary for effective cervical cancer prevention.
This study aimed to generate population-specific data on human Papillomavirus infections, and determine which of these, self-collected and provider-collected specimens, gives a higher estimate of the prevalence of human Papillomaviruses, including vaccine and non-vaccine-type human Papillomavirus.
Methods.
In this cross-sectional study, following a questionnaire-based collection of epidemiological data, self-, and provider-collected specimens, obtained from women 15−65 years of age, were analysed for human Papillomavirus types by a nested-multiplex polymerase chain reaction, and for cervical lesions by Pap testing.
HPV data were categorised according to risk type and vaccine types for further analysis.
Results.
The difference between the overall human Papillomavirus infection prevalences obtained with the self-collected specimens, 43.1% (95% CI of 38.0–51.0%) and that with the provider-collected samples, 23.3% (95% CI of 19.0–31.0%) were significant ( p≤0.001).
The prevalence of quadrivalent vaccine-type human Papillomaviruses was 12.3% with self-collected specimens, but 6.0% with provider-collected specimens.
For the nonavalent vaccine-types, the prevalences were 26.6% and 16.7% respectively.
There were multiple infections involving both vaccine-preventable and nonvaccine preventable high-risk human Papillomavirus genotypes.
Conclusion.
The Akuse subdistrict can, therefore, be said to have a high burden of human Papillomavirus infections, which included nonvaccine types, as detected with both self-collected and provider-collected specimens.
These imply that self-collection is to be given a higher consideration as a means for a population-based high-risk human Papillomavirus infections burdens assessment/screening.
Additionally, even with a successful implementation of the HPV vaccination, if introduced in Ghana, there is still the need to continue with the screening of women.
American Psychological Association (APA)
Awua, Adolf K.& Severini, Alberto& Wiredu, Edwin K.& Afari, Edwin A.& Zubach, Vanessa A.& Adanu, Richard M. K.. 2020. Self-Collected Specimens Revealed a Higher Vaccine- and Non-Vaccine-Type Human Papillomavirus Prevalences in a Cross-Sectional Study in Akuse. Advances in Preventive Medicine،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1130031
Modern Language Association (MLA)
Awua, Adolf K.…[et al.]. Self-Collected Specimens Revealed a Higher Vaccine- and Non-Vaccine-Type Human Papillomavirus Prevalences in a Cross-Sectional Study in Akuse. Advances in Preventive Medicine No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1130031
American Medical Association (AMA)
Awua, Adolf K.& Severini, Alberto& Wiredu, Edwin K.& Afari, Edwin A.& Zubach, Vanessa A.& Adanu, Richard M. K.. Self-Collected Specimens Revealed a Higher Vaccine- and Non-Vaccine-Type Human Papillomavirus Prevalences in a Cross-Sectional Study in Akuse. Advances in Preventive Medicine. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1130031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130031