Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System
Joint Authors
Silva, Márcia Vanusa da
Lima, Vera Lúcia de Menezes
Santos, Izabelly Bianca da Silva
Santos dos Santos, Bruno
Oliveira, João Ricardhis Saturnino de
Costa, Wêndeo Kennedy
Zagmignan, Adrielle
Lermen, Vilmar Luiz
Lermen, Maria Silvanete Benedito de Sousa
Ximenes, Rafael Matos
Soares, Luiz Alberto Lira
Nascimento da Silva, Luís Cláudio
Ferreira, Magda Rhayanny Assunção
Correia, Maria Tereza dos Santos
Paiva, Patrícia Maria Guedes
da Silva, Alexandre Gomes
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This work evaluated the antioxidant properties and in vivo antinociceptive and anti-inflammatory effects of extracts obtained from fruit peels of Myrciaria floribunda (H.
West ex Willd.) O.
Berg (Myrtaceae).
This plant is popularly known in Brazil as Cambuí or camboim.
Different extracts were submitted to comparative analysis to determine the content of selected phytochemical classes (levels of total phenols, flavonoids, and monomeric anthocyanins) and the in vitro antioxidant potentials.
The extract with higher potential was selected for in vivo evaluation of its antinociceptive and anti-inflammatory action.
Finally, the chemical characterization of this extract was performed by high-performance liquid chromatography (HPLC).
MfAE (extract obtained using acetone as solvent) showed the higher levels of phenols (296 mg GAE/g) and anthocyanins contents (35.65 mg Cy-3-glcE/g) that were associated with higher antioxidant activity.
MfAE also exhibited in vivo anti-inflammatory and analgesic propertiers.
This fraction inhibited the inflammatory and neurogenic phases of pain, and this effect was reversed by naloxone (suggesting the involvement of opioidergic system).
MfAE reduced the abdominal contortions induced by acetic acid.
The HPLC analysis revealed the presence of gallic acid (and its derivatives) and ellagic acid.
Taken together, these data support the use of M.
floribunda fruit peels for development of functional foods and nutraceutics.
American Psychological Association (APA)
Santos, Izabelly Bianca da Silva& Santos dos Santos, Bruno& Oliveira, João Ricardhis Saturnino de& Costa, Wêndeo Kennedy& Zagmignan, Adrielle& Nascimento da Silva, Luís Cláudio…[et al.]. 2020. Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1130061
Modern Language Association (MLA)
Santos, Izabelly Bianca da Silva…[et al.]. Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System. Advances in Pharmacological and Pharmaceutical Sciences No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1130061
American Medical Association (AMA)
Santos, Izabelly Bianca da Silva& Santos dos Santos, Bruno& Oliveira, João Ricardhis Saturnino de& Costa, Wêndeo Kennedy& Zagmignan, Adrielle& Nascimento da Silva, Luís Cláudio…[et al.]. Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System. Advances in Pharmacological and Pharmaceutical Sciences. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1130061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130061