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Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease
Joint Authors
Karádi, Kázmér
Kovács, Norbert
Lucza, Tivadar
Janszky, József
Makkos, Attila
Komoly, Sámuel
Kovács, Márton
Aschermann, Zsuzsanna
Harmat, Márk
Juhász, Annamária
Dorn, Krisztina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by numerous motor and nonmotor symptoms.
Neurocognitive disorders (NCD) are one of the most troublesome problems and their diagnosis is often challenging.
Methods.
We compared the sensitivity and specificity of several versions of Addenbrooke Cognitive Examination (ACE, ACE-III, and Mini-ACE) on 552 subjects with PD.
Normal cognition, mild and major NCD were judged in accordance with the respective criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition.
Subsequently, we applied the receiver operation characteristic (ROC) analysis in comparison of different education levels.
Results.
For subjects with education level 0–8 and 9–12 years, the ACE-III had the best discriminating capabilities for mild NCD (cut-off scores: 83.5 and 85.5 points, respectively), while Mini-ACE was the best for subjects having education > 12 years (cut-off score: 25.5 points).
For detecting major NCD, ACE-III had the best diagnostic accuracy in all levels of education (cut-off scores: 70.5, 77.5, and 78.5 points for subjects having education level 0–8, 9–12, and >12 years, respectively).
Conclusion.
ACE-III and its nested version, the Mini-ACE, had the best screening abilities for detecting mild and major NCD in PD.
American Psychological Association (APA)
Lucza, Tivadar& Aschermann, Zsuzsanna& Kovács, Márton& Makkos, Attila& Harmat, Márk& Juhász, Annamária…[et al.]. 2018. Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130270
Modern Language Association (MLA)
Lucza, Tivadar…[et al.]. Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease. Behavioural Neurology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1130270
American Medical Association (AMA)
Lucza, Tivadar& Aschermann, Zsuzsanna& Kovács, Márton& Makkos, Attila& Harmat, Márk& Juhász, Annamária…[et al.]. Comparing Sensitivity and Specificity of Addenbrooke’s Cognitive Examination-I, III and Mini-Addenbrooke’s Cognitive Examination in Parkinson’s Disease. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1130270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130270