PPAR-γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage
Joint Authors
Wang, Gaiqing
Li, Tong
Duan, Shu-na
Dong, Liang
Sun, Xin-gang
Xue, Fang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Purpose.
PPAR-γ is a transcriptional factor which is associated with promoting hematoma clearance and reducing neurological dysfunction after intracerebral hemorrhage (ICH).
Haptoglobin- (Hp-) hemoglobin- (Hb-) CD163 acts as a main pathway to Hb scavenging after ICH.
The effect of PPAR-γ on the Hp-Hb-CD163 signaling pathway has not been reported.
We hypothesized that PPAR-γ might protect against ICH-induced neuronal injury via activating the Hp-Hb-CD163 pathway in a rat ICH model.
Methods.
107 Sprague-Dawley rats were used in this research.
They were randomly allocated to 4 groups as follows: sham group, vehicle group, monascin-treated group, and Glivec-treated group.
Animals were euthanized at 3 days after the model was established successfully.
We observed the effects of PPAR-γ on the brain water content, hemoglobin levels, and the expressions of CD163 and Hp in Western blot and real-ime PCR; meanwhile, we measured hematoma volumes and edema areas by MRI scanning.
Result.
The results showed that PPAR-γ agonist significantly reduced hematoma volume, brain edema, and hemoglobin after ICH.
It also enhanced CD163 and Hp expression while PPAR-γ antagonist had the opposite effects.
Conclusions.
PPAR-γ promotes hematoma clearance and plays a protective role through the Hp-Hb-CD163 pathway in a rat collagenase infusion ICH model.
American Psychological Association (APA)
Wang, Gaiqing& Li, Tong& Duan, Shu-na& Dong, Liang& Sun, Xin-gang& Xue, Fang. 2018. PPAR-γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage. Behavioural Neurology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130323
Modern Language Association (MLA)
Wang, Gaiqing…[et al.]. PPAR-γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage. Behavioural Neurology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1130323
American Medical Association (AMA)
Wang, Gaiqing& Li, Tong& Duan, Shu-na& Dong, Liang& Sun, Xin-gang& Xue, Fang. PPAR-γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage. Behavioural Neurology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1130323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1130323