DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition
Joint Authors
Rosas-Pérez, Jaiver E.
Martínez Baquero, Diana A.
Barato Gómez, Paola Andrea
Iregui, Carlos
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis.
Materials and Methods.
Two different experiments were performed.
In the first experiment, hamsters’ right buccal pouches in group A (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n = 4) were painted with mineral oil only.
Two animals were sacrificed every three weeks to obtain histological samples and to evaluate pathological abnormalities.
After 12 weeks of exposition and with no macroscopic evidence of neoplasms, dexamethasone DM (1 mg/kg) was administered daily for 7 days to the last two animals in the study.
In the second experiment, DM was administered since DMBA exposition, following the same protocol as the first experiment.
Results.
The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10–12 weeks of exposition.
In addition, the frequency of histopathological lesions was higher.
Conclusion.
Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed.
American Psychological Association (APA)
Martínez Baquero, Diana A.& Barato Gómez, Paola Andrea& Iregui, Carlos& Rosas-Pérez, Jaiver E.. 2020. DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131663
Modern Language Association (MLA)
Martínez Baquero, Diana A.…[et al.]. DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1131663
American Medical Association (AMA)
Martínez Baquero, Diana A.& Barato Gómez, Paola Andrea& Iregui, Carlos& Rosas-Pérez, Jaiver E.. DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1131663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1131663