Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants
Joint Authors
Li, Yongsheng
Xu, Fang
Ren, Zhuxiao
Yan, Longli
Zheng, Xuaner
Yang, Haoming
Kang, Memnmeng
Yan, Huiheng
Zhong, Zhicheng
Miao, Jiayu
Wang, Jianlan
Yang, Jie
Xia, Xin
Wei, Wei
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
ANGPTL7 is a member of the angiogenin-like protein family.
Compared to other members, ANGPTL7 is the least known.
Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases.
However, there is no research about ANGPTL7 in neonates.
This study was designed to investigate the concentration of ANGPTL7 in cord blood of preterm infants.
Method.
Singleton infants born in November 2017 to June 2019 in the study hospital were enrolled in the study.
Maternal and neonatal clinical data were collected.
ANGPTL7 levels in cord blood and serum on the third day after birth were measured by an enzyme-linked immunosorbent assay.
Result.
A total of 182 infants were enrolled in this study.
Patients were categorized into two groups by gestational age (102 preterm, 80 full-term).
ANGPTL7 levels in preterm infants were significantly higher than that in full-term babies (t=15.4, P<0.001).
In multiple line regression analysis, ANGPTL7 levels independently correlated with gestational age (β=−0.556, P<0.001).
There is also no correlation between preterm outcomes and ANGPTL7 levels.
Cord blood levels of ANGPTL7 were significantly higher than those in serum on the third day after birth (t=13.88, P<0.001).
Conclusion.
Cord blood ANGPTL7 levels are higher in preterm infants than full-term babies.
The levels are independently influenced by gestational ages and attenuated significantly after birth.
The underlying mechanism needs to be further studied.
American Psychological Association (APA)
Xia, Xin& Ren, Zhuxiao& Yan, Longli& Zheng, Xuaner& Yang, Haoming& Kang, Memnmeng…[et al.]. 2020. Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants. BioMed Research International،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132120
Modern Language Association (MLA)
Xia, Xin…[et al.]. Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants. BioMed Research International No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1132120
American Medical Association (AMA)
Xia, Xin& Ren, Zhuxiao& Yan, Longli& Zheng, Xuaner& Yang, Haoming& Kang, Memnmeng…[et al.]. Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1132120
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132120