Target Enzymes Considered for the Treatment of Alzheimer’s Disease and Parkinson’s Disease
Joint Authors
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-09
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Various amyloidogenic proteins have been suggested to be involved in the onset and progression of neurodegenerative diseases (ND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Particularly, the aggregation of misfolded amyloid-β and hyperphosphorylated tau and α-synuclein are linked to the pathogenesis of AD and PD, respectively.
In order to care the diseases, multiple small molecules have been developed to regulate the aggregation pathways of these amyloid proteins.
In addition to controlling the aggregation of amyloidogenic proteins, maintaining the levels of the proteins in the brain by amyloid degrading enzymes (ADE; neprilysin (NEP), insulin-degrading enzyme (IDE), asparagine endopeptidase (AEP), and ADAM10) is also essential to cure AD and PD.
Therefore, numerous biological molecules and chemical agents have been investigated as either inducer or inhibitor against the levels and activities of ADE.
Although the side effect of enhancing the activity of ADE could occur, the removal of amyloidogenic proteins could result in a relatively good strategy to treat AD and PD.
Furthermore, since the causes of ND are diverse, various multifunctional (multitarget) chemical agents have been designed to control the actions of multiple risk factors of ND, including amyloidogenic proteins, metal ions, and reactive oxygen species.
Many of them, however, were invented without considerations of regulating ADE levels and actions.
Incorporation of previously created molecules with the chemical agents handling ADE could be a promising way to treat AD and PD.
This review introduces the ADE and molecules capable of modulating the activity and expression of ADE.
American Psychological Association (APA)
Kim, Namdoo& Lee, Hyuck Jin. 2020. Target Enzymes Considered for the Treatment of Alzheimer’s Disease and Parkinson’s Disease. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1132228
Modern Language Association (MLA)
Kim, Namdoo& Lee, Hyuck Jin. Target Enzymes Considered for the Treatment of Alzheimer’s Disease and Parkinson’s Disease. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1132228
American Medical Association (AMA)
Kim, Namdoo& Lee, Hyuck Jin. Target Enzymes Considered for the Treatment of Alzheimer’s Disease and Parkinson’s Disease. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1132228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132228