Fabrication and Application of a 3D-Printed Poly-ε-Caprolactone Cage Scaffold for Bone Tissue Engineering
Joint Authors
Sun, Yuchun
Wang, Siyi
Li, Rong
Xu, Yongxiang
Xia, Dandan
Zhu, Yuan
Yoon, Jungmin
Gu, Ranli
Liu, Xuenan
Zhao, Wenyan
Zhao, Xubin
Liu, Yunsong
Zhou, Yongsheng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Poly-ε-caprolactone (PCL) is a promising synthetic material in bone tissue engineering (BTE).
Particularly, the introduction of rapid prototyping (RP) represents the possibility of manufacturing PCL scaffolds with customized appearances and structures.
Bio-Oss is a natural bone mineral matrix with significant osteogenic effects; however, it has limitations in being constructed and maintained into specific shapes and sites.
In this study, we used RP and fabricated a hollow-structured cage-shaped PCL scaffold loaded with Bio-Oss to form a hybrid scaffold for BTE.
Moreover, we adopted NaOH surface treatment to improve PCL hydrophilicity and enhance cell adhesion.
The results showed that the NaOH-treated hybrid scaffold could enhance the osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMMSCs) both in vitro and in vivo.
Altogether, we reveal a novel hybrid scaffold that not only possesses osteoinductive function to promote bone formation but can also be fabricated into specific forms.
This scaffold design may have great application potential in bone tissue engineering.
American Psychological Association (APA)
Wang, Siyi& Li, Rong& Xu, Yongxiang& Xia, Dandan& Zhu, Yuan& Yoon, Jungmin…[et al.]. 2020. Fabrication and Application of a 3D-Printed Poly-ε-Caprolactone Cage Scaffold for Bone Tissue Engineering. BioMed Research International،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132310
Modern Language Association (MLA)
Wang, Siyi…[et al.]. Fabrication and Application of a 3D-Printed Poly-ε-Caprolactone Cage Scaffold for Bone Tissue Engineering. BioMed Research International No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1132310
American Medical Association (AMA)
Wang, Siyi& Li, Rong& Xu, Yongxiang& Xia, Dandan& Zhu, Yuan& Yoon, Jungmin…[et al.]. Fabrication and Application of a 3D-Printed Poly-ε-Caprolactone Cage Scaffold for Bone Tissue Engineering. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1132310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1132310