Acacetin Suppresses IL-1β-Induced Expression of Matrix Metalloproteinases in Chondrocytes and Protects against Osteoarthritis in a Mouse Model by Inhibiting NF-κB Signaling Pathways

Abstract EN

Osteoarthritis (OA) is a very common chronic joint dysfunction, and there is currently a poor understanding of its etiology and pathogenesis.

Therefore, there are no active disease-modifying drugs currently available for clinical treatment.

Several natural compounds have been shown to play a role in inhibiting OA progression.

The present study is aimed at investigating the curative effects of acacetin, a natural flavonoid compound, against OA.

Our results demonstrated that MMP-1, MMP-3, and MMP-13 were highly expressed in OA specimens.

Acacetin inhibited the interleukin-1β- (IL-1β-) induced expression of MMP-1, MMP-3, and MMP-13in chondrocytes by blocking nuclear factor-κB (NF-κB) signaling pathways.

Furthermore, we found that acacetin suppressed OA progression and inhibited the expression of MMP-1, MMP-3, and MMP-13 in ACLT-induced OA mice.

Taken together, our study revealed that acacetin may serve as a potential drug for treating OA.