QT Independent Ventricular Tachycardia Induced by Arsenic Trioxide

Abstract EN

Arsenic trioxide (ATO) is commonly known to cause QT prolongation with resultant ventricular tachycardia (VT).

VT, independent of QT prolongation, can be a complication of ATO.

We present a 46-year-old female who received ATO and during her hospital course had intermittent nonsustained VT.

All usual causes of VT were considered including reduced EF<35%, ischemia, electrolyte abnormalities, medications, and genetic polymorphisms; however, no specific cause was found.

After stopping therapy, the episodes of nonsustained VT ceased indicating that there is an association between ATO and VT.