cAMP Response Element Binding Protein Expression in the Hippocampus of Rhesus Macaques with Chronic Ephedrine Addiction
Joint Authors
Sun, Zongbo
Ma, Ye
Duan, Shouxing
Xie, Lei
Lv, Junyao
Huang, Jinzhuang
Lin, Zhirong
Guo, Ruiwei
Ma, Shuhua
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Drug addiction is classified as a chronic relapse nature brain disease with complicated neurobiology mechanisms.
There are an increasing number of researchers that are investigating the possible mechanisms for solving the thorny problem.
Methods.
The model of chronic addiction of rhesus monkey ephedrine was established, where changes in body weight and behavior were monitored.
The expression of cAMP response element binding protein (CREB) in the hippocampus of rhesus monkeys was identified by real-time PCR and Western blot.
Results.
We were successful in establishing the chronic ephedrine addiction model in the rhesus macaques.
They exhibited changes in body weight and behavior.
Immunofluorescence showed that CREB was expressed in the nucleus of the hippocampus, and the expression of CREB mRNA and protein in the hippocampus were increased by real-time PCR and Western blot.
The CREB positive expression in the hippocampus of the modeling group was significantly higher than in the control group.
Conclusions.
The changes of body weight and behavior of the rhesus monkeys after ephedrine chronic addiction were significant.
The changes of CREB in the hippocampus of rhesus macaques with ephedrine chronic addiction are important molecular mechanisms, and the upregulation of CREB may be involved in the physiological pathology and behavior process in individuals with chronic ephedrine addiction.
American Psychological Association (APA)
Sun, Zongbo& Ma, Ye& Duan, Shouxing& Xie, Lei& Lv, Junyao& Huang, Jinzhuang…[et al.]. 2017. cAMP Response Element Binding Protein Expression in the Hippocampus of Rhesus Macaques with Chronic Ephedrine Addiction. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134335
Modern Language Association (MLA)
Sun, Zongbo…[et al.]. cAMP Response Element Binding Protein Expression in the Hippocampus of Rhesus Macaques with Chronic Ephedrine Addiction. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1134335
American Medical Association (AMA)
Sun, Zongbo& Ma, Ye& Duan, Shouxing& Xie, Lei& Lv, Junyao& Huang, Jinzhuang…[et al.]. cAMP Response Element Binding Protein Expression in the Hippocampus of Rhesus Macaques with Chronic Ephedrine Addiction. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1134335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134335