Equilibrative Nucleoside Transporter 2: Properties and Physiological Roles

Joint Authors

Naes, Safaa M.
Ab-Rahim, Sharaniza
Mazlan, Musalmah
Abdul Rahman, Amirah

Source

BioMed Research International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-04

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Equilibrative nucleoside transporter 2 (ENT2) is a bidirectional transporter embedded in the biological membrane and is ubiquitously found in most tissue and cell types.

ENT2 mediates the uptake of purine and pyrimidine nucleosides and nucleobase besides transporting a variety of nucleoside-derived drugs, mostly in anticancer therapy.

Since high expression of ENT2 has been correlated with advanced stages of different types of cancers, consequently, this has gained significant interest in the role of ENT2 as a potential therapeutic target.

Furthermore, ENT2 plays critical roles in signaling pathway and cell cycle progression.

Therefore, elucidating the physiological roles of ENT2 and its properties may contribute to a better understanding of ENT2 roles beyond their transportation mechanism.

This review is aimed at highlighting the main roles of ENT2 and at providing a brief update on the recent research.

American Psychological Association (APA)

Naes, Safaa M.& Ab-Rahim, Sharaniza& Mazlan, Musalmah& Abdul Rahman, Amirah. 2020. Equilibrative Nucleoside Transporter 2: Properties and Physiological Roles. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134566

Modern Language Association (MLA)

Naes, Safaa M.…[et al.]. Equilibrative Nucleoside Transporter 2: Properties and Physiological Roles. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134566

American Medical Association (AMA)

Naes, Safaa M.& Ab-Rahim, Sharaniza& Mazlan, Musalmah& Abdul Rahman, Amirah. Equilibrative Nucleoside Transporter 2: Properties and Physiological Roles. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134566

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1134566