Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish
Joint Authors
Lu, Ping-Hsun
Lee, Hsun-Yao
Liou, Yan-Liang
Tung, Sheng-Fen
Kuo, Ko-Li
Chen, Yau-Hung
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Zhibai Dihuang Wan (ZDW) is an eight-herbal formula of traditional Chinese medicine.
Clinically, it regulated immune activity and was used to treat diabetes and renal disease.
In this study, we aimed to explore the nephroprotective effect of ZDW in an aristolochic acid- (AA-) intoxicated zebrafish model.
We used a green fluorescent kidney transgenic zebrafish to evaluate the nephroprotective effects of ZDW by recording subtle changes in the kidney.
Our results demonstrated that ZDW treatment can attenuate AA-induced kidney malformations (60% for AA-treated, 47% for pretreatment with ZDW, and 17% for cotreatment ZDW with AA, n=50).
Furthermore, we found that the expression levels of tnfα and mpo were decreased either in pretreatment or cotreatment groups.
In conclusion, our findings revealed that AA-induced nephrotoxicities can be attenuated by ZDW.
Therefore, we believe that zebrafish represent an efficient model for screening AA-protective Chinese medicine.
American Psychological Association (APA)
Lu, Ping-Hsun& Lee, Hsun-Yao& Liou, Yan-Liang& Tung, Sheng-Fen& Kuo, Ko-Li& Chen, Yau-Hung. 2020. Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134570
Modern Language Association (MLA)
Lu, Ping-Hsun…[et al.]. Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134570
American Medical Association (AMA)
Lu, Ping-Hsun& Lee, Hsun-Yao& Liou, Yan-Liang& Tung, Sheng-Fen& Kuo, Ko-Li& Chen, Yau-Hung. Nephroprotective Role of Zhibai Dihuang Wan in Aristolochic Acid-Intoxicated Zebrafish. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134570
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134570