Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis
Joint Authors
Xia, Huanhuan
Zhao, Liangcai
Yan, Zhihan
Du, Yao
Hu, Wenyi
Bai, Guanghui
Zheng, Hong
Gao, Hong-Chang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Amyloid β (Aβ) deposition has been implicated in the pathogenesis of Alzheimer’s disease.
However, the early effect of Aβ deposition on metabolism remains unclear.
In the present study, thus, we explored the metabolic changes in the hippocampus and serum during first 2 weeks of Aβ25–35 injection in rats by using an integrated method of NMR-based metabolomics and ANOVA-simultaneous component analysis (ASCA).
Our results show that Aβ25–35 injection, time, and their interaction had statistically significant effects on the hippocampus and serum metabolome.
Furthermore, we identified key metabolites that mainly contributed to these effects.
After Aβ25–35 injection from 1 to 2 weeks, the levels of lactate, N-acetylaspartate, creatine, and taurine were decreased in rat hippocampus, while an increase in lactate and decreases in LDL/VLDL and glucose were observed in rat serum.
Therefore, we suggest that the reduction in energy and lipid metabolism as well as an increase in anaerobic glycolysis may occur at the early stage of Aβ25–35 deposition.
American Psychological Association (APA)
Du, Yao& Zheng, Hong& Xia, Huanhuan& Zhao, Liangcai& Hu, Wenyi& Bai, Guanghui…[et al.]. 2017. Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135884
Modern Language Association (MLA)
Du, Yao…[et al.]. Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1135884
American Medical Association (AMA)
Du, Yao& Zheng, Hong& Xia, Huanhuan& Zhao, Liangcai& Hu, Wenyi& Bai, Guanghui…[et al.]. Early Effect of Amyloid β-Peptide on Hippocampal and Serum Metabolism in Rats Studied by an Integrated Method of NMR-Based Metabolomics and ANOVA-Simultaneous Component Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1135884