EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR

Abstract EN

Long noncoding RNAs play an essential role in bladder cancer progression.

The role of long noncoding RNA EGFR-AS1 in bladder cancer needs further study.

We used clinical specimens to analyze the relationship between EGFR-AS1 and bladder cancer patients’ characteristics.

The functional experiments and mechanism studies were performed using qRT-PCR, transwell assay, survival analysis, and correlation analysis.

We found that high expression of EGFR-AS1 was nearly related to aggressive bladder cancer and indicated poor prognosis for patients.

The functional experiments in vivo and in vitro suggested that EGFR-AS1 promoted the proliferation and invasion of bladder cancer cells.

Mechanically, EGFR-AS1 promoted the expression of EGFR by inhibiting the degradation of EGFR mRNA, thereby promoting the metastasis of bladder cancer.

In addition, EGFR-AS1/EGFR may be involved in the immune-related pathways of bladder cancer.

These studies indicate that the EGFR-AS1/EGFR pathway may be a potential diagnostic marker and therapeutic target for bladder cancer.